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Molecular Oncology Group



Normal epithelial cells have a directionality called "cell polarity." The apical-basal polarity is the most representative of these directions. This apical-basal polarity is regulated by "cell polarity proteins". Most cancers are known to originate from epithelial cells, and abnormalities in apical-basal cell polarity and cell polarity proteins are observed in these various types of cancer cells. Our research group is focusing on the analysis of abnormalities in cell polarity proteins observed in cancer cells to understand the pathophysiological roles of the abnormalities of polarity proteins.



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