Publications

• Kudo R., Igarashi K., Soga T.*, Ishikawa T.*, Saito Y.*, Comprehensive metabolome analysis of intracellular metabolites in cultured cells. STAR Protoc., 3, 101531 (2022). PMID: 35819883 *Corresponding authors

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• Saito Y.*, Matsuda S., Ohnishi N., Endo K., Ashitani S., Ohishi M., Ueno A., Tomita M., Ueda K., Soga T.*, Muthuswamy S.K.* Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in breast cancer. Commun. Biol., 5, 403 (2022). doi: 10.1038/s42003-022-03363-3. PMID: 35501367 *Corresponding authors

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• Saito Y.*, Soga T*. Amino acid transporters as emerging therapeutic targets in cancer. Cancer Sci., 112, 2958-2965 (2021). PMID: 34091991 *Corresponding authors

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• Saito Y., Li L., Coyaud E., Luna A., Sander C., Raught B., Asara J.M., Brown M., Muthuswamy S.K. LLGL2 rescues nutrient stress by promoting Leu uptake in ER+ breast cancer. Nature 569, 275-279 (2019). PMID: 30996345 

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• Saito, Y., Desai, R.R., Muthuswamy, S.K. Reinterpreting Polarity and Cancer: The changing landscape from tumor suppression to tumor promotion. BBA Reviews on Cancer 1869, 103-116 (2018). PMID: 29369778

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• Saito, Y., Murata-Kamiya, N., Ohba, Y., Hirayama, T., Hatakeyama, M. Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. J. Exp. Med. 207: 2157-2174 (2010). PMID: 20855497

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• Saito, Y., Edpalina, R.R., Abe, S. Isolation and characterization of salmonid telomeric and centromeric satellite DNA sequences. Genetica 131: 157-166 (2006). PMID: 17180439

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• Milano, D., Natividad, R., Saito, Y., Luo, C., Muthuswamy, S.K, Asthagiri, A. Positive quantitative relationship between EMT and contact-initiated sliding on fiber-like tracks. Biophysical Journal 111, 1569-1574 (2016). PMID: 27705778

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• Yamahashi, Y., Saito, Y., Murata-Kamiya, N., Hatakeyama, M. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization. J. Biol. Chem. 286: 44576-44584 (2011). PMID: 22072711

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• Safari, F., Murata-Kamiya, N., Saito, Y., Hatakeyama, M. Mammalian pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Proc. Natl. Acad. Sci. USA. 108: 14938-14943 (2011). PMID: 21873224

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• Takahashi, A., Tsutsumi, R., Kikuchi, I., Obuse, C., Saito, Y., Seidi, A., Karisch, R., Fernandez, M., Cho, T., Ohnishi, N., Rozenblatt-Rosen, O., Meyerson, M., Neel, B.G., Hatakeyama, M. SHP2 tyrosine phosphatase converts parafibromin/cdc73 from a tumor suppressor to an oncogenic driver. Mol. Cell 43: 45-56 (2011). PMID: 21726809

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• Lu, H., Murata-Kamiya, N., Saito, Y., Hatakeyama, M. Role of PAR1/MARK kinases in the morphogenetic activity of Helicobacter pylori CagA. J. Biol. Chem. 284: 23024-23036 (2009). PMID: 19553659

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• Umeda, M., Murata-Kamiya, N., Saito, Y., Ohba, Y., Takahashi, M., Hatakeyama, M. Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. J. Biol. Chem. 284: 22166-22172 (2009). PMID: 19546211

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• Lu, H., Saito, Y., Umeda, M., Murata-Kamiya, N., Zhang, H., Higashi, H., Hatakeyama, M. Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA. Cancer Sci. 99: 2004-2011 (2008). PMID: 19016760

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• Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S., Hatakeyama, M. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial polarity. Nature 447: 330-333 (2007). PMID: 17507984

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• Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R.M., Azuma, T., Hatakeyama, M. Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferantiation in gastric epithelial cells. Oncogene 26: 4617-4626 (2007). PMID: 17237808